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Pclp homeless series#
They then migrate in order to colonize a series of haematopoietic sites that include the fetal liver, thymus, spleen, omentum and, eventually, the bone marrow, giving rise to sequential generations of blood cells. Haematopoietic stem cells first appear at two sites in the developing embryo: in the yolk sac and from splanchnopleural mesoderm in the aorta-gonad-mesonephros (AGM) region of the embryo proper (reviewed in Dieterlen-Lièvre, 1998 Godin et al, 1999 Keller et al, 1999 Medvinksy & Dzierzak, 1999). This review will be restricted to haematopoietic stem cells and their progeny. It therefore follows that an understanding of stem cell biology has enormous implications for the treatment and cure of diseases affecting many millions of individuals worldwide ( Fuchs & Segre, 2000 Watt & Hogan, 2000 Weissman, 2000a, b). Stem cells are the basic cellular units responsible for the development of all tissue and organ systems in the body.
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The importance of adhesion receptors in haematopoiesis